Antileishmanial Activity ofHandroanthus serratifolius(Vahl) S. Grose (Bignoniaceae)

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Antileishmanial Activity of Handroanthus serratifolius (Vahl) S. Grose (Bignoniaceae)

This study aimed to evaluate the leishmanicidal activity of ethanol extract, fractions, and isolated substance from Handroanthus serratifolius against Leishmania amazonensis. Furthermore, this activity was related to cytotoxicity, and the selectivity index was determined. The ethanol extract was obtained by maceration of the stem powder, and the extract was subjected to fractionation on chromat...

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Impact of Forpus xanthopterygius (Spix, 1824) (Aves, Psittacidae) on flowers of Handroanthus serratifolius (Vahl.) S. O. Grose (Bignoniaceae).

Handroanthus serratifolius produces flowers during the dry season in the Cerrado biome, and it may be an important food source to some bird species. For Psittacidae species, like Forpus xanthopterygius, flowers are important in their diet. This study intended to characterize the behavior of F.xanthopterygius and evaluate the damage to the flowering and in the reproduction of H. serratifolius. F...

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Antileishmanial activity of polycyclic derivatives.

33 polycyclic derivatives have been studied and tested on Leishmania donovani and L. major promastigotes. Their antileishmanial activity was assessed in vitro and an assay of their cytotoxicity was realized on human myelomonocytic cell line. The reference molecules used in the assays were amphotericin B and pentamidine. Among the compounds tested, 29 possess an antileishmanial activity; 25 of t...

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Antileishmanial activity of lapachol analogues.

The antileishmanial activity of lapachol, isolapachol, and dihydrolapachol, along with soluble derivatives (potassium salt) and acetate was obtained. All the compounds were assayed against metacyclic promastigotes of two different species of Leishmania associated to tegumentar leishmaniasis: L. amazonensis and L. braziliensis. All compounds presented significant activity, being isolapachol acet...

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Antileishmanial activity of the terpene nerolidol.

The activity of nerolidol, a sesquiterpene used as a food-flavoring agent and currently under testing as a skin penetration enhancer for the transdermal delivery of therapeutic drugs, was evaluated against Leishmania species. Nerolidol inhibited the growth of Leishmania amazonensis, L. braziliensis, and L. chagasi promastigotes and L. amazonensis amastigotes with in vitro 50% inhibitory concent...

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ژورنال

عنوان ژورنال: Evidence-Based Complementary and Alternative Medicine

سال: 2017

ISSN: 1741-427X,1741-4288

DOI: 10.1155/2017/8074275